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自清雍正以来,乐家老店同仁堂被钦定为“御药供奉”,至乐家第八代已声名大震。病家闻名纷纷求药,而日本浪人小野勾结在乐家长大的曹化伦,蓄谋夺走密方药谱。 曹化伦盗方被老东家乐宏达撞见,行凶纵火,烧毁乐家细料药库;又勾结御药房白太监扣押御药银子,竟使老店雪上加霜,无钱制药,无药可售。王爷误以为乐家“拿搪”,一怒下令撤销乐家御药供奉,另行招标。面对内外交困,乐宏达老人为保住二百年老字号,毅然隔代传印,将堂印传给孙子乐宏达。 乐宏达临危受命,在妻子徐瑞珍帮助下,以海底捞月之功,夺回御药供奉。并得到光绪皇帝的赐匾。曹化伦又怂恿王爷,下令老店不得在民间售药,只供宫廷。乐宏达体味到“进则为良相,退则为良医”,“进而济世,退而济民”,“抗旨”卖药。乐宏达力助孙子,利用大总管李莲英的病情,一药回天。西太后终于开禁。 流落北京被乐家收留的女伶丛玉珠,暗恋乐宏达,然而为营救乐宏达出狱,舍身将自己嫁给曹化伦。 甲午战争,清军赴朝鲜抗敌。乐宏达赶造出十万包“诸葛行军散”,赠送将士,却被药材商人借机抬价,欠下巨款。年关债主逼债,乐宏达借贷无门,愤而变卖祖宅。药材商人得知赠药原因,慨然放弃债权。老店又一次绝处逢生。 丫头兰香之父胡七死里逃生,被诬追捕。乐家掩护胡七,却被曹化伦出卖。乐宏达将兰香收为义孙女。在徐瑞珍的撮合下,兰香与乐宏达喜结良缘。 八国联军炮轰大栅栏,老店店堂化于一炬。乐宏达命乐宏达、徐瑞珍陪同怀有身孕的兰香逃出京城,为乐家留下后代。小野率日本兵闯入乐家搜取密方,乐宏达〈应该是乐阔海〉以毒酒相酬,与之同归于尽。 乐宏达潜回京城,痛不欲生。他找到了爷爷珍藏的秘方药谱,将其藏入乐宏达的棺材。曹化伦有疑,趁夜开棺,徐瑞珍和义伶响九霄设计将曹吓死。 老店在废墟上重张,乐宏达却因饱受摧残离别人世。弥留之际,正值他的儿子乐同仁满岁“抓周”。在满桌的官帽、元宝、笔墨、绸缎之间,小同仁却抓起了《同仁堂药典》……
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